TOP GUIDELINES OF PKRRATING

3B). R526 from the loop among αJ and αI anchors the C-terminal portion of the activation loop by forming a salt bridge with E458 at The bottom of αEF. Q459 stabilizes the HRD motif by a hydrogen bond to the main chain carbonyl of R413. The tip in the activation section is stabilized by a hydrogen bond between Y454 and E480 from αF. from the FTF